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· Deep & Superficial Neuromodulation
AI Defined
The ultimate solution for "individual variability" in non-invasive neuromodulation.
Integrating tFUS Technology with AI to automatically generate precise treatment protocols for every patient.
View Publications →
Precision Non-invasive BCI
Adaptive Phase Correction
Exclusive Acoustic Field Correction
Sound waves refract and scatter when penetrating heterogeneous skulls. Our hybrid simulation engine calculates and compensates for phase aberrations.
BCI-Sonics | 华超神控 - Official Website
OFF: Uncorrected

Refraction & Defocusing (散射)

ON: BCI-Sonics Correction

Precise Focusing in 1.5mm

In-House AI Protocol Generation
Utilizing our proprietary AI model, we automatically calculate and generate personalized treatment parameters based on each patient's skull structure.
Outcome Consistency
Solving inconsistency caused by individual differences
Deep Nuclei + Superficial Synergy
Multi-layer ring arrays and phased deflection technology enable full network coverage modulation from the deep thalamus to the superficial cortex.
GLOBAL FIRST
*Supported by recent studies (Mesik et al., 2024)
Dual Closed-Loop System
Neuromodulation:
Real-time feedback for timing optimization.
EFG
PCD
BBBO Application:
Activated only when barrier opens.
From "E&M" to "Acoustic"
Traditional "Electric" and "Magnetic" technologies face physical bottlenecks of "Shallow Depth" and "Low Precision".
tFUS (Transcranial Focused Ultrasound) is the only non-invasive technology capable of achieving both deep brain coverage and millimeter-level precision.
Generational Leap in Neuromodulation
The Next Evolution
TMS
Low spatial resolution (cm level), difficult to reach deep nuclei accurately.
Limitation:
Transcranial Magnetic Stimulation
Magnetic
tDCS
Current diffuses widely, lacking focus.
Limitation:
Transcranial Direct Current
Electrical
TI
Limited spatial resolution, hard to customize.
Limitation:
Temporal Interference
Electrical
tFUS (LIFU)
Deep Reach, <1.5mm Precision, AI Flexibility.
All-Around Champion:
Low Intensity Focused Ultrasound
Acoustic
OUR TECH

Mechanical Precision,
Neural Awakening

BCI-Sonics firmly chooses the LIFU (Low-Intensity Focused Ultrasound) route. Unlike HIFU which destroys tissue with high heat, we utilize the pure mechanical effects of ultrasound to modulate neural activity.

  • Acoustic Radiation Force Ultrasound beams generate minute mechanical pressure at the target, physically "pushing" or "stretching" neuronal membranes.
  • Mechano-sensitive Channels (Piezo/TRP) Membrane deformation opens mechano-sensitive ion channels, triggering ion influx to precisely induce or suppress neural impulses.
LIFU Neuromodulation Mechanism
MACRO VIEW: Neuron Target MICRO VIEW: Cell Membrane & Ion ChannelsAcoustic ForcePiezo ChannelSignal Triggered
Correction Engine
Exclusive Hybrid Acoustic Field Correction
Skull heterogeneity is a huge challenge. Our system can complete transcranial 3D acoustic field reconstruction and phase compensation in ＜10 seconds, controlling target positioning accuracy within 1.5mm.
Hardware Innovation
Global First: Full-Depth Synergy
The world's first system to achieve synergistic stimulation of deep nuclei (such as the thalamus) and the superficial cortex, resulting in significantly better clinical outcomes.
AI Defined
Rejecting the "one-size-fits-all" approach. BCI-Sonics uses a full-stack self-developed AI engine
to transform traditional "empirical medicine" into data-based "precision computation", ensuring every treatment is precise and effective.
Personalized Neuromodulation
AI Engin
Skull BoundaryTargetSIMULATION STATUS:● COMPLETESKULL CORRECTION: ONTIME: 8.2s

Hyper-Fast Simulation

From Hours to < 10s

Traditional acoustic field simulation takes extremely long. Utilizing our self-developed AI model and physics-informed neural networks, we can complete full 3D acoustic field reconstruction and skull attenuation correction in <10 seconds.

  • Fully Automatic Segmentation (No manual labeling)
  • "Scan & Treat" Workflow
Parameter Space Search
AI adjusts not only power but also globally optimizes across billions of parameter combinations like intensity, duty cycle, pulse timing, and beamforming.
01
Cracking Individual Variability: Automated Protocol Generation
The biggest challenge in non-invasive neuromodulation is "inconsistent efficacy". Our AI engine searches for the optimal solution for each patient in a massive parameter space.
Individual Adaptation
Automatically fine-tunes the incident angle based on patient skull acoustic transmittance and target depth to ensure consistent effective stimulation dose at the target.
02
Outcome Consistency
Significantly improves treatment response rates, solving the long-standing industry problem of "same parameters, different results".
03
Dynamic Closed-Loop: The System "Understands" the Brain
Closed-Loop Safety
EEG
Neuromodulation Mode
Real-time capture of EEG signals (e.g., Alpha/Theta rhythms). AI judges neural excitability based on feedback and automatically adjusts stimulation timing (Phase-Locked).
For Neuromodulation
PCD
BBB Opening Mode
Real-time monitoring of microbubble cavitation signals. Once inertial cavitation is detected, the system lowers intensity in milliseconds, ensuring the entire process remains in the safe stable cavitation range.
For Neuromodulation
Scientific Height × Industrial Depth
Bringing together top wisdom from neuroscience, acoustic physics, and artificial intelligence.
The core team possesses complete medical device lifecycle experience from prototype, clinical registration to commercialization.
Full-Chain Innovation Team
Interdisciplinary Powerhouse
Science & AI Leaders
•Former R&D executives of Global Fortune 500 Medical Giants.
•Multiple MICCAI competition champions.
•Led product definition and R&D for large-scale medical imaging AI platforms deployed in hundreds of hospitals.
Acoustic Design & Simulation
Strategy & Operations
Scientific Visionaries
Engineering Architects
•Deep expertise in ultrasound transducer design and complex acoustic field simulation.
•Developed hybrid acoustic signal algorithms for precise correction of transcranial phase aberration.
•Experience from prototype to clinical registration approval.
•Elite background from Global Top 10 Universities.
•Led cross-border M&A and medical sector investments worth hundreds of millions of dollars.
•Expertise in medical device commercialization pathways.
Global Strategy
Selected Publications
Academic Origins, Clinical Applications
Selected Representative Achievements

05

2025-12

435
0
(Few-shot Learning)

The core technology for achieving high-precision organ/brain segmentation algorithms under data constraints has been transferred to brain target recognition.

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05

2025-12

473
0
Intelligent segmentation of medical images

Few-shot learning allows models to acquire new concepts from minimal examples, resembling human learning efficiency.

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05

2025-12

483
0
Weakly supervised cerebral vascular segmentation

Weakly supervised cerebral vascular segmentation uses limited annotations to accurately delineate blood vessels in brain images.

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05

2025-12

455
0
Complex Sound Field Simulation and Compatibility

Complex Sound Field Simulation and Compatibility involves modeling intricate acoustic environments to ensure optimal sound performance and device interoperability.

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Deep Research Heritage
Published 50+ peer-reviewed papers, Total Impact Factor > 150
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Contact Us
We look forward to your inquiry and working together to advance the future of brain science and intelligent medicine.
Get in Touch
Office Location
Office & Contact
Room 605, Building 6, Skybridge HQ
No. 968 Jinzhong Road, Changning District
Shanghai, China (Zip: 200335)
General Inquiry
深厚的科研积淀
深厚的科研积淀
深厚的科研积淀
info@bcisonics.com
Careers
We are always looking for top talents in acoustic physics, neural engineering, and AI algorithms. Join us in defining the next generation of medical technology.
© 2025 BCI-Sonics (Shanghai) Technology Co., Ltd.
BCI-SONICS
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